Acnos Hotel stands on Nguyễn Thị Nghĩa street in the Bến Thành area of District 1, a stretch of cafés, small restaurants and shops. Wayne's Coffee and Phở Hùng are both 50 m from the hotel, and September 23 Park is 100 m away, a small green space in the centre of the district. The Chùa An Lạc pagoda, a Buddhist temple, is 250 m from the hotel.
Ben Thanh Market, a covered market for food, clothes and souvenirs, is 550 m from the hotel, and Ben Thanh Station is 450 m away. In the evening the streets around the market fill with food stalls, a short walk from the front door. Saigon Railway Station, the city's main rail terminal, is 2.2 km away, and Tan Son Nhat International Airport is 5.3 km from the property, a taxi or ride-hailing trip rather than a walk.
Sri Mariamman Temple, a Hindu temple with a richly decorated entrance tower, is 300 m from the hotel, and the Ho Chi Minh City Fine Arts Museum, housed in a colonial-era building, is 600 m away. Independence Palace, the former presidential palace, is 750 m away, and Tao Dan Park, a green space in the centre of District 1, is 450 m away. Both the museum and the palace sit within District 1, so they are easy to see in the same visit.